Fully analyzed information on every sample sequenced yesterday is at your fingertips each morning, including: 

  • Transmission events, with all new and currently active transmission chains highlighted for assessment and action.

  • Resistance prediction

  • Resistance-associated genes and mutations

Action-oriented summary information, including status of infection control actions taken, efficiently coordinates action by infection control teams, while interactive information-rich visualizations are available for expert review.  

 

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TRANSMISSION DETECTION MODULE

The transmission detection module highlights new transmission chains, based on recursively computed SNP-level difference between genomes.  New candidate transmission clusters are presented in a form designed to guide action by infection control to validate and if appropriate take steps to intervene to promptly curtail outbreak as it begins.

 

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ANTIBIOGRAM PREDICTION MODULE

Sequence-based predictions of susceptible (S) and resistant (R) for all relevant drugs are furnished. Resistance calls are given along with the genomic element (either resistance gene or genes, or resistance associated mutations) that prompted the predicted R phenotype.  Phenotypic antibiogram data can be imported when available, for comparison.  

The Antibiogram Prediction Module is not yet FDA-cleared, and so is RUO, but is suited to support a hospital-validated LDT.

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THE RESISTOME MODULE

All resistance genes and resistance-associated mutations found in the sequence are summarized, with sequence matches to resistance elements in 4 distinct curated databases (CARD, ResFinder, ARG-ANNOT, and PATRIC).  The Resistome Module furnishes far greater detail than any PCR-based molecular diagnostic assay.

“Next Gen Diagnostics’ system has been at work at Addenbrooke’s only since March 2018, and has already helped both catch and curtail outbreaks, as well as enabled us to recognize that a set of samples we thought to be related was in fact not, saving enormous effort and sparing patients needless concern. We believe this is the future of infection control.”